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Article: RNA editing of serotonin receptor disrupts transactivation of G-protein RhoA.
- Article from:
- Proteomics Weekly
- Article date:
- March 8, 2004
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2004 MAR 8 - (NewsRx.com & NewsRx.net) -- RNA editing of the human serotonin 5-HT2C receptor disrupts transactivation of the small G-protein RhoA.
"The human serotonin 5-HT2C receptor undergoes adenosine-to-inosine RNA editing at five positions, generating multiple receptor isoforms with altered G-protein coupling properties. In the current study, we demonstrate that RNA editing regulates the pattern of intracellular signaling. The non-edited human 5-HT2C receptor isoform INI activates phospholipase D via the G(13) heterotrimer G-protein," scientists writing in the journal Molecular Pharmacology report.
"We present evidence that transactivation of the ...