Article: RNA editing of serotonin receptor disrupts transactivation of G-protein RhoA.

2004 MAR 8 - (NewsRx.com & NewsRx.net) -- RNA editing of the human serotonin 5-HT2C receptor disrupts transactivation of the small G-protein RhoA.

"The human serotonin 5-HT2C receptor undergoes adenosine-to-inosine RNA editing at five positions, generating multiple receptor isoforms with altered G-protein coupling properties. In the current study, we demonstrate that RNA editing regulates the pattern of intracellular signaling. The non-edited human 5-HT2C receptor isoform INI activates phospholipase D via the G(13) heterotrimer G-protein," scientists writing in the journal Molecular Pharmacology report.

"We present evidence that transactivation of the ...

Related newspaper, magazine, and journal articles:

 
 
Newsweek Harper's Magazine The Washington Post Chicago Tribune Crain's Chicago Business PRNewswire Pediatric News The Nation Advertising Age The Economist (US) A FREE trial gives you access to over 80 million articles! Access over 6,500 publications with a FREE trial!