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Article: VEGF plays a fundamental role in the promotion of osteoblastic metastasis.
- Article from:
- Angiogenesis Weekly
- Article date:
- April 2, 2004
CopyrightCOPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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2004 APR 2 - (NewsRx.com & NewsRx.net) -- VEGF plays a fundamental role in the promotion of prostate cancer metastasis.
"Human prostate cancer has a high predisposition to metastasize to bone, resulting in the formation of osteoblastic metastases. The mechanism through which prostate cancer cells promote osteoblastic lesions is undefined. Vascular endothelial growth factor (VEGF) has been implicated as a mediator of osteoblast activity," researchers in the United States report.
"In the present study, we examined if prostate cancer cells promote osteoblastic activity through VEGF. We found that LNCaP and C4-2B prostate cancer cell lines and primary tumor ...
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