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Article: Polymorphism in gene promoter linked to increased bilirubin and HDL levels.
- Article from:
- Cardiovascular Week
- Article date:
- March 29, 2004
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2004 MAR 29 - (NewsRx.com & NewsRx.net) -- A microsatellite polymorphism in the heme oxygenase-I gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease.
"Heme oxygenase 1 (HO-1) is involved in the generation of the endogenous antioxidant bilirubin which exerts beneficial effects against arteriosclerosis. A (GT) repeat polymorphism in the HO-1 promoter region modulates HO-1 expression in response to oxidative stress. Recently, this polymorphism has been reported to protect from coronary artery disease in Orientals," scientists in Austria report.
"We intended to confirm this observation in Caucasians. We ...