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Article: Altering conditions of DNA immunization allows control of immune response.
- Article from:
- Genomics & Genetics Weekly
- Article date:
- April 2, 2004
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2004 APR 2 - (NewsRx.com & NewsRx.net) -- Altering the cellular localization of expressed protein and the immunization route in DNA immunization allows manipulation of the immune response.
According to published research from the United States, "DNA immunization by intramuscular (IM) injection induces Th1 responses, whereas gene gun (GG) immunization into the skin stimulates Th2 responses. Three ovalbumin (OVA) cDNA constructs, in which OVA is cytoplasmic (CYT), secreted (SECR), or transmembrane (TM), were compared in immunization studies using intramuscular injection or biolistic bombardment of the skin."
"Gene gun immunization with OVA-CYT or OVA-TM ...