|
|
Article: Alanine is critical to TNP-470 specificity for methionine aminopeptidase-2.
- Article from:
- Angiogenesis Weekly
- Article date:
- April 16, 2004
CopyrightCOPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
2004 APR 16 - (NewsRx.com & NewsRx.net) -- Alanine is critical to TNP-470 specificity for methionine aminopeptidase-2.
According to published research from the United States, "TNP-470, the first antiangiogenic small molecule to enter clinical trials, targets methionine aminopeptidase-2 (MetAP-2), a metalloprotease that cleaves the N-terminal methionine of proteins. Previously, biochemical binding, in vivo yeast studies, and structural studies of human methionine aminopeptidase-2 bound to TNP-470 and its analogs fumagillin and ovalicin revealed that these compounds exhibit specificity for MetAP-2 over its family member MetAP-1. To further elucidate the nature of ...