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Article: CREB protein encourages the progression of hepatocellular carcinoma.
- Article from:
- Angiogenesis Weekly
- Article date:
- April 23, 2004
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2004 APR 23 - (NewsRx.com & NewsRx.net) -- CREB protein encourages the progression of hepatocellular carcinoma.
"Tumor microenvironment controls the selection of malignant cells capable of surviving in stressful and hypoxic conditions. The transcription factor, cyclic AMP-responsive element binding (CREB) protein, activated by multiple extracellular signals, modulates cellular response by regulating the expression of a multitude of genes. Previously, we have demonstrated that two cystein residues, at the DNA binding domain of CREB, mediate activation of CREB-dependent gene expression at normoxia and hypoxia," scientists in Israel report.
"The ...