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Article: Role of CREB in CCAAT/enhancer-binding protein beta gene described.
- Article from:
- Obesity, Fitness & Wellness Week
- Article date:
- April 24, 2004
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2004 APR 24 - (NewsRx.com & NewsRx.net) -- The role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis is described in a recent issue of the Journal of Biological Chemistry.
"The proximal promoter of the C/EBPbeta gene possesses dual cis regulatory elements (TGA1 and TGA2), both of which contain core CREB binding sites. Comparison of the activities of C/EBPbeta promoter-reporter genes with 5'-truncations or site-directed mutations in the TGA elements showed that both are required for maximal promoter function. Electrophoretic mobility shift and chromatin immunoprecipitation (ChIP) analyses with antibodies ...