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Article: Membrane lipid composition affects receptor function in Saccharomyces.
- Article from:
- Drug Week
- Article date:
- May 14, 2004
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2004 MAY 14 - (NewsRx.com & NewsRx.net) -- Scientists have discovered genetic evidence of a role for membrane lipid composition in the regulation of soluble NEM-sensitive factor receptor function in Saccharomyces cerevisiae.
"SEC9 and SPO20 encode SNARE proteins related to the mammalian SNAP-25 family. Sec9p associates with the SNAREs Sso1/2p and Snc1/2p to promote the fusion of vesicles with the plasma membrane. Spo20p functions with the same two partner SNAREs to mediate the fusion of vesicles with the prospore membrane during sporogenesis," investigators in the United States report.
"A chimeric molecule, in which the helices of Sec9p that bind to ...