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Article: Phosphorylated HSP27 essential for association of RhoA with PKC alpha.
- Article from:
- Proteomics Weekly
- Article date:
- May 10, 2004
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2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Phosphorylated HSP27 is essential for acetylcholine-induced association of RhoA with PKC alpha.
According to a study from the United States, "Reorganization of the cytoskeleton and association of contractile proteins are important steps in modulating smooth muscle contraction. Heat shock protein (HSP) 27 has significant effects on actin cytoskeletal reorganization during smooth muscle contraction. We investigated the role of phosphorylated HSP27 in modulating acetylcholine-induced sustained contraction of smooth muscle cells from the rabbit colon by transfecting smooth muscle cells with phosphomimic (3D) or ...