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Article: Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.
- Article from:
- Environmental Health Perspectives
- Article date:
- April 1, 2004
- Author:
CopyrightCOPYRIGHT 2004 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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We tested 200 pesticides, including some of their isomers and metabolites, for agonism and antagonism to two human estrogen receptor (hER) subtypes, hER[alpha] and hER[beta], and a human androge receptor (hAR) by highly sensitive transactivation assays using Chinese hamster ovary cells. The test compounds were classified into nine groups: urganochlorines, diphenyl ethers, organophosphorus pesticides, pyrethroids, carbamates, acid amides, triazines, ureas, and others. These pesticides wet tested at concentrations
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It has been well documented that several chemicals from agricultural, industrial, and household sources possess endocrine-disrupting properties, ...