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Article: Human frontal cortex development depends on G protein-coupled receptor.
- Article from:
- Health & Medicine Week
- Article date:
- May 17, 2004
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2004 MAY 17 - (NewsRx.com & NewsRx.net) -- The development of the human frontal cortex is G protein-coupled receptor-dependent.
"The mammalian cerebral cortex is characterized by complex patterns of anatomical and functional areas that differ markedly between species, but the molecular basis for this functional subdivision is largely unknown. Here, we show that mutations in GPR56, which encodes an orphan G protein-coupled receptor (GPCR) with a large extracellular domain, cause a human brain cortical malformation called bilateral frontoparietal polymicrogyria (BFPP)," scientists writing in the journal Science report.
"BFPP is characterized by ...