Article: Clinical Trial of Treatment for Sleep Disorders Ends in Success; Phase 2 Discovery Announces Positive Results for PD-6735 in Primary Insomnia.

Business Editors/Health/Medical Writers

CINCINNATI--(BUSINESS WIRE)--May 20, 2004

Phase 2 Discovery (www.phase2d.com) today reported results from a phase 2 clinical trial that demonstrates that PD-6735, a melatonin analog, produced statistically significant improvements in sleep latency in patients with primary insomnia.

In the randomized, placebo-controlled cross-over study, 40 patients with moderate primary insomnia received placebo, and three doses of PD-6735--20 mg, 50 mg, and 100 mg. Patients experienced statistically significant improvements in sleep latency after each dose of PD-6735--a 31-percent improvement after 20 mg, a 32-percent ...

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