Article: Effects of ultrasound and trolamine salicylate phonophoresis on delayed-onset muscle soreness. (includes commentary and author response)

Phonophoresis consists of using ultrasound to drive a drug through the skin and into underlying tissues. [1,2] In theory, ultrasound can enhance the transdermal delivery of certain pharmacologic agents to skeletal muscle tissue, bursae, tendons, and so on.

Thus, phonophoresis offers the potential advantage of delivering a pharmacologic agent in a relatively safe, painless, and easy manner to structures that lie somewhat deep within the body.

Several forms of drugs have been administered with phonophoresis. [2,3] Studies using animal models have suggested that ultrasound may enhance the percutaneous absorption of local anesthetics and anti-inflammatory ...

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