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Article: Thiol depletion aids bax-induced programmed cell death in lung cancer cells.
- Article from:
- Gene Therapy Weekly
- Article date:
- June 3, 2004
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2004 JUN 3 - (NewsRx.com & NewsRx.net) -- Thiol depletion aids bax-induced programmed cell death in lung cancer cells.
According to recent research from the United States, "the utility of dominant acting proapoptotic molecules to induce cell death in cancer cells is being evaluated in preclinical studies and clinical trials. We recently developed a binary adenoviral expression system to enable the efficient gene transfer of Bax and other proapoptotic molecules. Using this system, overexpression of Bax protein in four non-small-cell lung cancer (NSCLC) cell lines, H1299, A549, H226 and H322, was evaluated.
"The H322 line exhibited significant resistance ...