Limiting opiates in the treatment of chronic pain.(Tips from Other Journals)

Opium has been used for thousands of years to treat pain. When the morphine alkaloid was identified as the active ingredient in opium, pharmacologic production of opiates became possible. Widespread use and abuse of opiates led to strict regulatory controls. By the 1940s, a physician's prescription was required to obtain opiates legally in the United States. Ballantyne and Mao review some new ideas about opiates that have come out of bench-top and clinical research and their possible implications for the management of chronic pain.

The authors begin their review by noting that most of the literature on opioid therapy is composed of uncontrolled case series of short ...

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