Article: Stat3 activation may be a critical event during skin tumor promotion.

2004 JUN 15 - (NewsRx.com & NewsRx.net) -- Stat3 activation may be a critical event during skin tumor promotion.

"In the present study, we have investigated the possible role of signal transducers and activators of transcription (STATs), particularly Stat3, in mouse skin tumor promotion and multistage carcinogenesis," wrote investigators in the journal Cancer Research.

"Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin. In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors ...

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