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Article: Neuropeptide Y presynaptic actions reduced in obese rat hypothalamus.
- Article from:
- Health & Medicine Week
- Article date:
- June 14, 2004
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2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Neuropeptide Y (NPY) presynaptic actions are reduced in the hypothalamic mpPVN of obese (Fa/fa), but not lean, Zucker rats in vitro.
"Neuropeptide Y (NPY) profoundly enhances feeding when injected intracerebroventricularly, or directly into hypothalamic nuclei, such as the paraventricular nucleus (PVN). Paradoxically, NPY has a reduced action on feeding in obese Zucker rats relative to lean Zucker rats, although the obese rats have much higher levels of hypothalamic NPY expression. GABAergic inputs to a subpopulation of medial parvocellular PVN (mpPVN) neurons are sensitive to NPY," scientists in Canada report.
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