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Article: Germ-line variants of the MYH gene affect colorectal cancer susceptibility.
- Article from:
- Obesity, Fitness & Wellness Week
- Article date:
- June 19, 2004
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2004 JUN 19 - (NewsRx.com & NewsRx.net) -- Germ-line variants of the MYH gene affect colorectal cancer susceptibility.
"Biallelic germ-line variants of the 8-hydroxyguanine repair gene MYH have been associated with multiple colorectal adenomas that display somatic G:C-->T:A transversions in APC. However, the effect of single germ-line variants has not been widely studied.
"To examine the relationship between monoallelic MYH variants and susceptibility to sporadic colorectal cancer (CRC), 92 cases of sporadic CRC, 19 cases of familial CRC not meeting the Bethesda guidelines, 17 cases with multiple adenomas, and 53 normal blood donors were screened for 8 ...