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Article: New class of lipid absorption inhibitor from sage discovered.
- Article from:
- Drug Week
- Article date:
- June 25, 2004
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2004 JUN 25 - (NewsRx.com & NewsRx.net) -- Carnosic acid represents a new class of lipid absorption inhibitor from sage.
According to a study from Japan, "The methanolic extract from the leaves of Salvia officinalis (sage) showed significant inhibitory effect on serum triglyceride elevation in olive oil-loaded mice (500 and 1,000 mg/kg, p.o.) and inhibitory activity (IC[subscript]50: 94 mcg/mL) against pancreatic lipase, which is participated in digestion of lipids."
"Through bioassay-guided separation using the inhibitory activity against pancreatic lipase activity, 4 abietan-type diterpenes (carnosic acid, carnosol, royleanonic acid, ...