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Article: Overexpression of myotrophin triggers myocardial hypertrophy and heart failure.
- Article from:
- Genomics & Genetics Weekly
- Article date:
- July 9, 2004
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2004 JUL 9 - (NewsRx.com & NewsRx.net) -- Knowledge about myotrophin overexpression-induced cardiac hypertrophy will help researchers develop preventive strategies.
"Cardiac hypertrophy and heart failure remain leading causes of death in the United States. Many studies have suggested that, under stress, myocardium releases factors triggering protein synthesis and stimulating myocyte growth," researchers in the United States report.
"We identified and cloned myotrophin, a 12-kDa protein from hypertrophied human and rat hearts. Myotrophin (whose gene is localized on human chromosome 7q33) stimulates myocyte growth and participates in cellular interaction ...