|
|
Article: CXCR4 and its ligand CXCL12 regulate angiogenesis in the intestinal tract.
- Article from:
- Health & Medicine Week
- Article date:
- July 12, 2004
CopyrightCOPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
2004 JUL 12 - (NewsRx.com & NewsRx.net) -- CXCR4 and its ligand CXCL12 regulate angiogenesis in the intestinal tract.
According to a study from the United States, "mice genetically deficient in the chemokine receptor CXCR4 or its ligand stromal cell-derived factor (SDF)-1/ CXCL12 die perinatally with marked defects in vascularization of the gastrointestinal tract. The aim of this study was to define the expression and angiogenic functions of microvascular CXCR4 and SDF-1/ CXCL12 in the human intestinal tract."
"Studies of human colonic mucosa in vivo and primary cultures of human intestinal microvascular endothelial cells (HIMEC) in vitro showed that the ...