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Article: Depressed serum erythropoietin in pregnant women with elevated blood lead.
- Article from:
- Archives of Environmental Health
- Article date:
- November 1, 1991
- Author:
CopyrightCOPYRIGHT 1991 Heldref Publications. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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ASSOCIATIONS between lead (Pb) exposure and symptoms of anemia have been known for centuries. [1] Most modern investigators have ascribed the anemia of Pb poisoning to its well-known adverse effects on heme synthesis [2] or to other known effects of Pb, including shortened red cell survival, [3] ineffective erythropoiesis, [4] and inhibition of erythrocyte pyrimidine-5'-nucleotidase activity. [5] Grandjean et al. [6] recently described delayed blood regeneration capacity in Pb-exposed workers who had experienced normal hemoglobin (Hgb) concentrations and hematocrits prior to blood donation. That report led us to hypothesize that Pb may inhibit the production of ...
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