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Article: RhoA and zeta PKC control different modes of chemokine-induced LFA-1 activation.
- Article from:
- Proteomics Weekly
- Article date:
- July 19, 2004
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2004 JUL 19 - (NewsRx.com & NewsRx.net) -- RhoA and zeta PKC control different modes of chemokine-induced LFA-1 activation.
"Chemokines regulate rapid leukocyte adhesion by triggering a complex modality of integrin activation," immunologists in Italy noted.
In a recent study, C. Giagulli and colleagues at the University of Verona found that "the small GTPase RhoA and the atypical zeta PKC differently control lymphocyte LFA-1 high-affinity state and rapid lateral mobility induced by chemokines."
"Activation of LFA-1 high-affinity state and lateral mobility is controlled by RhoA through the activity of distinct effector regions, demonstrating ...