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Article: Metabolism of P2 receptor agonists aids cystic fibrosis research.
- Article from:
- Vaccine Weekly
- Article date:
- July 21, 2004
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2004 JUL 21 - (NewsRx.com & NewsRx.net) -- The metabolism of P2 receptor agonists in human airways has implications for mucociliary clearance and cystic fibrosis.
"Extracellular nucleotides are among the most potent mediators of mucociliary clearance (MCC) in human lungs. However, clinical trials revealed that aerosolized nucleotides provide only a transient improvement of MCC to patients diagnosed with cystic fibrosis (CF). In this study, we identified the mechanism that eliminates extracellular nucleotides from human airways," investigators in the United States report.
"Polarized primary cultures of human bronchial epithelial cells were impermeable to ...