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Article: Raf and RhoA cooperate to transform intestinal epithelial cells.
- Article from:
- Obesity, Fitness & Wellness Week
- Article date:
- August 7, 2004
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2004 AUG 7 - (NewsRx.com & NewsRx.net) -- Raf and RhoA cooperate to transform intestinal epithelial cells and induce growth resistance to transforming growth factor beta.
"Although unregulated activation of the Ras/Raf/mitogen-activated protein kinase kinase/Erk signaling pathway is believed to be a central mechanism by which many cell types undergo oncogenic transformation, recent studies indicate that activation of Raf kinase by oncogenic Ras is not sufficient to cause tumorigenic transformation in intestinal epithelial cells. Thus, identification of signaling proteins and pathways that interact with Raf to transform intestinal epithelial cells may be critical ...