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Article: Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis.(Research)
- Article from:
- Emerging Infectious Diseases
- Article date:
- July 1, 2004
- Author:
CopyrightCOPYRIGHT 2004 U.S. National Center for Infectious Diseases. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little is known about the load of SARS-CoV in oral droplets. We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both throat wash (9.58 x [10.sup.2] to 5.93 x [10.sup.6] copies/mL) and saliva (7.08 x [10.sup.3] to 6.38 x [10.sup.8] copies/mL) from all specimens of 17 consecutive probable SARS case-patients, supporting the possibility of transmission through oral droplets. Immunofluorescence study showed replication of SARS-CoV in the cells derived from throat wash, ...