Article: Genomic effects of stimulated bone estrogen receptors determined.

2004 AUG 16 - (NewsRx.com & NewsRx.net) -- The genomic effects of stimulated bone estrogen receptors in osteosarcoma have been determined.

"Estrogens exert many important effects in bone, a tissue that contains both estrogen receptors alpha and beta (ERalpha and ERbeta)," endocrinologists in the United States explained.

"To compare the actions of these receptors," F. Stossi and colleagues at the University of Illinois "generated U2OS human osteosarcoma cells stably expressing ERalpha or ERbeta, at levels comparable with those in osteoblasts," and "characterized their response to 17beta-estradiol (E2) over time using Affymetrix GeneChip microarrays to ...

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