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Article: Reassortment with avian influenza virus attenuates influenza virus.
- Article from:
- Drug Week
- Article date:
- September 3, 2004
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2004 SEP 3 - (NewsRx.com & NewsRx.net) -- Reassortment with an avian influenza virus attenuates a human H9N2 influenza virus in a mammalian host.
According to published research from Japan and China, "In order to develop a surrogate virus strain for production of an inactivated influenza vaccine against a human H9N2 virus, A/Hong Kong/1073/99 (HK1073: H9N2) was co-infected in embryonated chicken eggs with an apathogenic avian influenza virus, A/Duck/Czechoslovakia/56 (Dk/Cz: H4N6), for gene segment reassortment. Multiple-gene reassortants obtained were examined for replication in mammalian hosts in vitro and in vivo by infecting MDCK cells and by intranasal ...