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Article: Mast cells may serve as a viral reservoir for HIV-1.
- Article from:
- Health & Medicine Week
- Article date:
- August 30, 2004
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2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Mast cells may serve as a viral reservoir for HIV-1.
"Evidence that human progenitor mast cells are susceptible to infection with CCR5-tropic strains of HIV-1 and that circulating HIV-1-infected FcERIalpha+ cells with a similar progenitor phenotype have been isolated from AIDS patients has led to speculation that mast cells may serve as a potential reservoir for infectious HIV-1, wrote scientists in the United States.
"In this study," said J.B. Sundstrom and colleagues, "progenitor mast cells, developed in vitro from CD34+ cord blood stem cells, were experimentally infected with the CCR5-tropic strain HIV-1Bal ...