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Article: Midkine promoter-based gene therapy decimates malignant glioma.
- Article from:
- Obesity, Fitness & Wellness Week
- Article date:
- September 4, 2004
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2004 SEP 4 - (NewsRx.com & NewsRx.net) -- Midkine promoter-based gene therapy decimates malignant glioma.
"Little is known concerning promoters or gene therapy specific for malignant glioma. To explore the potential use of midkine promoter in gene therapy for malignant glioma, we constructed a midkine promoter-based conditionally replicating adenovirus (Ad-MK). Midkine was overexpressed in malignant glioma tissues but cyclooxygenase-2 was not," scientists writing in the journal Oncology Reports state.
"The midkine promoter activity of the 600-bp fragment was 2 orders of magnitude higher in midkine-positive glioma cells than in midkine-negative primary ...