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Article: Alkaloid riddelliine induces mutations in liver cII gene of Big Blue rats.
- Article from:
- Gastroenterology Week
- Article date:
- September 6, 2004
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2004 SEP 6 - (NewsRx.com & NewsRx.net) -- The carcinogenic pyrrolizidine alkaloid riddelliine induces mutations in the liver cII gene of transgenic Big Blue rats.
According to published research from the United States, "Riddelliine is a naturally occurring pyrrolizidine alkaloid that forms a number of different mononucleotide and dinucleotide adducts in DNA. It is a rodent carcinogen and a potential human hazard via food contamination. To examine the mutagenicity of riddelliine, groups of six female transgenic Big Blue rats were gavaged with 0.1, 0.3, and 1.0 mg riddelliine per kg body weight. The middle and high doses resulted in liver tumors in a previous ...