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Article: SELF-CLEAVING AS METHOD OF DEATH HAMMERHEAD RIBOZYME SERVES AS GENE EXPRESSION POWER TOOL.(control of gene expression in mammalian genes through RNA self-cleavage; scientific applications)
- Article from:
- BIOWORLD Today
- Article date:
- October 4, 2004
- Author:
CopyrightCOPYRIGHT 2004 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Byline: Anette Breindl, Science Editor
For people who think shark when they hear hammerhead, the hammerhead ribozyme's mechanism of action sounds like a feeding frenzy gone bad: self-cleavage leading to destruction.
But it is a novel method for scientists to control gene expression in mammalian cells, and it has potential applications across a wide range of research and clinical areas.
Proof of principle of the method was published in the Sept. 23, 2004, issue of Nature, in a paper titled "Exogenous control of mammalian gene expression through modulation of RNA self-cleavage."
Current methods of controlling gene expression are ...