Article: Haloperidol impairs human learning and error-related negativity.

2004 OCT 4 - (NewsRx.com & NewsRx.net) -- The dopamine-disrupting agent haloperidol impairs error-related negative learning in humans.

"Humans are able to monitor their actions for behavioral conflicts and performance errors," scientists in the United States explained. "Growing evidence suggests that the error-related negativity (ERN) of the event-related cortical brain potential (ERP) may index the functioning of this response monitoring system and that the ERN may depend on dopaminergic mechanisms."

P.J. Zirnheld and coauthors at Indiana University "examined the role of dopamine in ERN and behavioral indices of learning by administering either 3 mg of ...

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