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Article: Guinea-pig artery can be used to study side-effect potential of migraine drugs.
- Article from:
- Drug Week
- Article date:
- October 15, 2004
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2004 OCT 15 - (NewsRx.com & NewsRx.net) -- Scientists have investigated the involvement of 5-HT[subscript]1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.
According to a study from Germany, "Using a series of triptans we characterized in vitro the 5-hydroxytryptamine (5-HT) receptor that mediates the contraction in guinea-pig iliac arteries moderately precontracted by prostaglandin F[subscript]2alpha (PGF[subscript]2alpha). Additionally, we investigated by reverse-transcriptase polymerase chain reaction (RT-PCR) which triptan-sensitive receptor is present in this tissue."
S. Jahnichen and colleagues of the Freie ...