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Article: Preferential pindolol 5-HT[subscript]1A occupancy reduced in depressed patients.
- Article from:
- Science Letter
- Article date:
- October 26, 2004
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2004 OCT 26 - (NewsRx.com & NewsRx.net) -- Preferential occupancy of 5-HT[subscript]1A autoreceptors by pindolol is reduced in depressed patients.
"Using positron emission tomography and the selective 5-HT[subscript]1A receptor radioligand [[superscript]11C]WAY100635," scientists in England "previously demonstrated a preferential occupancy of 5-HT[subscript]1A autoreceptors, compared to postsynaptic receptors by pindolol in healthy volunteers."
"We have speculated that preferential occupancy may be clinically important for the purported actions of pindolol in accelerating the antidepressant effects of selective serotonin re-uptake inhibitors (SSRIs)," ...