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Article: Endogenous Ang II may modulate inward calcium current in the failing heart.
- Article from:
- Pharma Business Week
- Article date:
- November 1, 2004
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2004 NOV 1 - (NewsRx.com & NewsRx.net) -- Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart.
Scientists in the United States report, "The influence of intracellular and extracellular angiotensin II (Ang II) on the L-type calcium current of cardiomyocytes isolated from cardiomyopathic hamsters was investigated."
W.C. De Mello and J. Monterrubio of the University of Puerto Rico wrote, "The results indicated that Ang II (10[superscript]-8 mmol/L), added to the bath, increased the peak inward calcium current (I-Ca) density by 37[+ or -]3.4% (P
"Moreover, in control animals, no change in the rate of I-Ca ...