Article: CYP19/aromatase is the major enzyme in methadone metabolism in placenta.

2004 NOV 4 - (NewsRx.com & NewsRx.net) -- CYP19/aromatase is the major enzyme in methadone metabolism in term placentas from healthy pregnancies, biochemists at the University of Texas determined.

"Methadone pharmacotherapy is considered the standard for treatment of the pregnant heroin/opioid addict. One of the factors affecting the transfer kinetics of opioids across human placenta and their levels in the fetal circulation is their metabolism by the tissue.

"The aim of this investigation is to identify the enzyme(s) responsible for the metabolism of methadone, determine the kinetics of the reaction, and the metabolites formed utilizing placental tissue ...

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