Article: Merck knew of Vioxx heart attack risk 4 years ago, researchers say.(Knight Ridder Newspapers)

Byline: Linda Loyd

Swiss researchers are reporting Thursday in an international medical journal that evidence was clear and overwhelming in 2000 that Vioxx doubled the rate of heart attacks and Merck & Co. Inc. should have withdrawn the drug four years ago.

The analysis, by Peter Juni and colleagues at the University of Berne, looked at results from 18 Vioxx studies, all sponsored by Merck, that showed that 41 patients out of about 11,000 Vioxx users by late 2000 had suffered heart attacks, twice the rate of those receiving a placebo or other painkillers.

The study, funded by the Swiss National Science Foundation, analyzed 18 randomized ...

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