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Article: Liposomes prepared from BCG possessed adjuvant activity in vivo.
- Article from:
- Immunotherapy Weekly
- Article date:
- November 10, 2004
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2004 NOV 10 - (NewsRx.com & NewsRx.net) -- Liposomes prepared from phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette-Guerin (BCG) activated dendritic cells and possessed adjuvant activity in vivo.
According to a study from Canada, "Liposome vesicles could be formed at 65 degrees C from the chloroform-soluble, total polar lipids (TPL) extracted from Mycobacterium bovis bacillus Calmette-Guerin (BCG). Mice immunized with ovalbumin (OVA) entrapped in TPL liposomes produced both anti-OVA antibody and cytotoxic T lymphocyte responses. Murine bone marrow-derived dendritic cells were activated to secrete interleukin-6 (IL-6), IL-12, and tumor ...