Article: Mast cell phenotype induction regulated by several independent genes.

2004 NOV 10 - (NewsRx.com & NewsRx.net) -- Mast cell phenotype induction is regulated by several independent genes.

"In order to better understand the mechanisms governing display of mast cell characteristics in human myeloid cells, we have studied the mast cell phenotype in human promyelocytic (HL-60) and myelocytic (U-937, TPH-1) vs. basophilic (KU-812) and mast cell (HMC-1) lines, in part also in skin mast cells and blood monocytes, at mRNA and protein level before and after stimulation with mast cell growth factors," scientists writing in the journal Experimental Dermatology report.

"In unstimulated cells, mRNA for the stem cell factor (SCF) ...

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