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Article: Arthropod-derived histamine-binding protein prevents allergic asthma.
- Article from:
- Respiratory Therapeutics Week
- Article date:
- November 8, 2004
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2004 NOV 8 - (NewsRx.com & NewsRx.net) -- Arthropod-derived histamine-binding protein prevents murine allergic asthma.
According to a study from an international team of researchers, "Because histamine receptor type I blockade attenuates allergic asthma, we asked whether complete neutralization of histamine by an arthropod-derived, high affinity histamine-binding protein (EV131) would prevent allergic asthma. Intranasal administration of EV131 given before antigen challenge in immunized mice prevented airway hyperreactivity by 70%, and abrogated peribronchial inflammation, pulmonary eosinophilia, mucus hypersecretion, and IL-4 and IL-5 secretion."
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