|
|
Article: Alpha-KGDH may contribute to generation of oxidative stress in mitochondria.
- Article from:
- Biotech Week
- Article date:
- November 17, 2004
CopyrightCOPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
2004 NOV 17 - (NewsRx.com & NewsRx.net) -- A recent report describes generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase.
"Alpha-Ketoglutarate dehydrogenase (alpha-KGDH), a key enzyme in the Krebs' cycle, is a crucial early target of oxidative stress (Tretter and Adam-Vizi, 2000). The present study demonstrates that alpha-KGDH is able to generate H[subscript]2O[subscript]2 and, thus, could also be a source of reactive oxygen species (ROS) in mitochondria[superscript]+)," scientists writing in the Journal of Neuroscience report.
L. Tretter and colleagues of Semmelweis University in Budapest explained, ...