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Article: Kinetics of paclitaxel release from blended-polymer microspheres evaluated.
- Article from:
- Medical Devices & Surgical Technology Week
- Article date:
- December 12, 2004
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2004 DEC 12 - (NewsRx.com & NewsRx.net) -- The kinetics of paclitaxel release from blended-polymer microspheres have been characterized.
In a recent study from Canada, "[m]icrospheres were prepared from paclitaxel and binary polymer blends incorporating 1, 3, 40k and 100k g/mol PLLA."
"Thermal analysis was performed by DSC and in vitro paclitaxel release profiles were determined at 37 degrees C in phosphate buffer using an HPLC assay," explained R.T. Liggins and coauthors at the University of British Columbia. "In microspheres made with 3k/40k PLLA blends, the glass transition (T[subscript]g), crystallinity and melting temperature (T[subscript]m) all ...