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Article: Ca[superscript]2+ sensitivity of release appears to be regulated by Ca[superscript]2+ content.
- Article from:
- Health & Medicine Week
- Article date:
- December 13, 2004
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2004 DEC 13 - (NewsRx.com & NewsRx.net) -- Sarcoplasmic reticulum Ca[superscript]2+ refilling controls recovery from Ca[superscript]2+-induced Ca[superscript]2+ release refractoriness in heart muscle.
According to recent research published in the journal Circulation Research, "In cardiac muscle Ca[superscript]2+-induced Ca[superscript]2+ release (CICR) from the sarcoplasmic reticulum (SR) is initiated by Ca[superscript]2+ influx via L-type Ca[superscript]2+ channels. At present, the mechanisms underlying termination of SR Ca[superscript]2+ release, which are required to ensure stable excitation-contraction coupling cycles, are not precisely known. However, the ...