Article: Nrf2 essential for efficacy of oltipraz against urinary bladder carcinogenesis.

2004 DEC 21 - (NewsRx.com & NewsRx.net) -- Nrf2 is essential for the efficacy of oltipraz against urinary bladder carcinogenesis.

"The induction of phase 2 detoxifying enzymes, such as UDP-glueuronosyltransferases (UGTs), in response to an array of naturally occurring and synthetic agents, such as oltipraz (4-methyl-5-[2-pyrazinyll-1,2-dithiole-3thione), provides an effective means of protection against a variety of carcinogens.

"Transcription factor Nrf2 is an essential regulator of the inducible expression of detoxifying enzyme genes by chemopreventive agents. In this study, we investigated in Nrf2-deficient mice the susceptibility to the urinary ...

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