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Article: Growth factors mobilize CXCR4 low/negative primitive HSC from bone marrow.
- Article from:
- Obesity, Fitness & Wellness Week
- Article date:
- December 25, 2004
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2004 DEC 25 - (NewsRx.com & NewsRx.net) -- Growth factors mobilize CXCR4 low/negative primitive hematopoietic stem cells from the bone marrow.
According to a study from the United States, "The chemokine receptor CXCR4 is expressed by CD34+ hematopoietic stem/progenitor cells (HSC/HPC). Several investigators have suggested that expression of CXCR4 may be an important characteristic of HSC/HPC.
"We studied the dynamic expression of CXCR4 during growth factor-induced mobilization of HSC in a clinically relevant nonhuman primate model, Papio anubis (baboons). We evaluated whether CXCR4 expression in HSC/HPC varies during steady-state hematopoiesis as well ...