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Article: Natural antibodies sustain differentiation and maturation of dendritic cells.
- Article from:
- World Disease Weekly
- Article date:
- December 21, 2004
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2004 DEC 21 - (NewsRx.com & NewsRx.net) -- Natural antibodies sustain differentiation and maturation of human dendritic cells.
"The differentiation and maturation of dendritic cells (DCs) is governed by various signals in the microenvironment. Monocytes and DCs circulate in peripheral blood, which contains high levels of natural antibodies (NAbs). NAbs are germ-line-encoded and occur in the absence of deliberate immunization or microbial aggression. To assess the importance of NAbs in the milieu on DC development, we examined the status of DCs in patients with X-linked agammaglobulinemia, a disease characterized by paucity of B cells and circulating antibodies," ...