Article: Retinal degeneration alters CREB levels in murine suprachiasmatic nucleus.

2004 DEC 28 - (NewsRx.com & NewsRx.net) -- Retinal degeneration alters CREB activity in the murine suprachiasmatic nucleus (SCN).

In a study from Spain, the "effect of cone- and rod-cell loss on the activation of transcription factor CREB (by phosphorylation at Ser[superscript]133) was examined in the pacemaker of mammals," the SCN.

"For this purpose, brain sections of rd/rd and wild-type C3H mice were immunolabeled with a polyclonal antibody that recognises p-CREB, i.e., the activated form of the protein," explained C. Alvarez-Lopez and coauthors at the University of Oviedo. "Both rd/rd and wild-type mice maintained in constant darkness showed a ...

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