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Article: Azelaic acid for rosacea.(Literature Review & Commentary)
- Article from:
- Townsend Letter for Doctors and Patients
- Article date:
- January 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 The Townsend Letter Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Two hundred fifty-one patients with papulopustular rosacea with persistent erythema and telangiectasia were randomly assigned to receive, in double-blind fashion, a 15% azelaic acid gel or 0.75% metronidazole gel. The respective treatments were applied topically twice a day for 15 weeks. Azelaic acid gel was more effective than metronidazole gel, as demonstrated by a greater reduction in the mean number of lesions (-12.9 vs. -10.7; p = 0.003) and by a greater mean percent decrease in inflammatory lesions (-72.7% vs. -55.8%; p
Comment: Azelaic acid is a nontoxic 9-carbon dicarboxylic acid that has been shown to be effective as a topical treatment for acne vulgaris, ...