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Article: Anticonvulsant studied for primary insomnia.(Clinical Rounds)
- Article from:
- Family Practice News
- Article date:
- February 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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NEW YORK -- The anticonvulsant tiagabine is effective in maintaining and enhancing deep sleep in adults with primary insomnia, Thomas Roth, Ph.D., reported during a poster session at the annual meeting of the American Psychiatric Association.
The first randomized study of tiagabine (Gabitril) in patients with primary insomnia found tiagabine 8 mg and 12 mg doses significantly maintained and enhanced "deeper" nonrapid eye movement stages of sleep, and did not cause next-day residual sedation at 4 mg and 8 mg.
Based on these results, 8 mg of the selective [gamma]-aminobutyric acid (GABA) reuptake inhibitor would be the target dose, said Dr. Roth, director ...